[HTML][HTML] Cysteine cathepsins: A long and winding road towards clinics

M Biasizzo, U Javoršek, E Vidak, M Zarić… - Molecular Aspects of …, 2022 - Elsevier
Biomedical research often focuses on properties that differentiate between diseased and
healthy tissue; one of the current focuses is elevated expression and altered localisation of
proteases. Among these proteases, dysregulation of cysteine cathepsins can frequently be
observed in inflammation-associated diseases, which tips the functional balance from
normal physiological to pathological manifestations. Their overexpression and secretion
regularly exhibit a strong correlation with the development and progression of such …