Alternative splicing in angiogenesis
Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a
given gene, which can have distinct functions. In fact, splice isoforms can have opposing
functions and there are many instances whereby a splice isoform acts as an inhibitor of
canonical isoform function, thereby adding an additional layer of regulation to important
processes. Angiogenesis is an important process that is governed by alternative splicing
mechanisms. This review focuses on the alternative spliced isoforms of key genes that are …
given gene, which can have distinct functions. In fact, splice isoforms can have opposing
functions and there are many instances whereby a splice isoform acts as an inhibitor of
canonical isoform function, thereby adding an additional layer of regulation to important
processes. Angiogenesis is an important process that is governed by alternative splicing
mechanisms. This review focuses on the alternative spliced isoforms of key genes that are …
Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. In fact, splice isoforms can have opposing functions and there are many instances whereby a splice isoform acts as an inhibitor of canonical isoform function, thereby adding an additional layer of regulation to important processes. Angiogenesis is an important process that is governed by alternative splicing mechanisms. This review focuses on the alternative spliced isoforms of key genes that are involved in the angiogenesis process; VEGF-A, VEGFR1, VEGFR2, NRP-1, FGFRs, Vasohibin-1, Vasohibin-2, HIF-1α, Angiopoietin-1 and Angiopoietin-2.
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