CRISPR/Cas9-mediated SARM1 knockout and epitope-tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages
CG Doran, R Sugisawa, M Carty, F Roche… - Journal of Biological …, 2021 - ASBMB
SARM1 is a toll/interleukin-1 receptor-domain containing protein, with roles proposed in
both innate immunity and neuronal degeneration. Murine SARM1 has been reported to
regulate the transcription of chemokines in both neurons and macrophages; however, the
extent to which SARM1 contributes to transcription regulation remains to be fully understood.
Here, we identify differential gene expression in bone-marrow-derived macrophages
(BMDMs) from C57BL/6 congenic 129 ES cell-derived Sarm1−/− mice compared with wild …
both innate immunity and neuronal degeneration. Murine SARM1 has been reported to
regulate the transcription of chemokines in both neurons and macrophages; however, the
extent to which SARM1 contributes to transcription regulation remains to be fully understood.
Here, we identify differential gene expression in bone-marrow-derived macrophages
(BMDMs) from C57BL/6 congenic 129 ES cell-derived Sarm1−/− mice compared with wild …
