Peripheral neuropathy as a component of skeletal disease in diabetes
AT Beeve, JM Brazill, EL Scheller - Current Osteoporosis Reports, 2019 - Springer
AT Beeve, JM Brazill, EL Scheller
Current Osteoporosis Reports, 2019•SpringerAbstract Purpose of Review The goal of this review is to explore clinical associations
between peripheral neuropathy and diabetic bone disease and to discuss how nerve
dysfunction may contribute to dysregulation of bone metabolism, reduced bone quality, and
fracture risk. Recent Findings Diabetic neuropathy can decrease peripheral sensation
(sensory neuropathy), impair motor coordination (motor neuropathy), and increase postural
hypotension (autonomic neuropathy). Together, this can impair overall balance and …
between peripheral neuropathy and diabetic bone disease and to discuss how nerve
dysfunction may contribute to dysregulation of bone metabolism, reduced bone quality, and
fracture risk. Recent Findings Diabetic neuropathy can decrease peripheral sensation
(sensory neuropathy), impair motor coordination (motor neuropathy), and increase postural
hypotension (autonomic neuropathy). Together, this can impair overall balance and …
Purpose of Review
The goal of this review is to explore clinical associations between peripheral neuropathy and diabetic bone disease and to discuss how nerve dysfunction may contribute to dysregulation of bone metabolism, reduced bone quality, and fracture risk.
Recent Findings
Diabetic neuropathy can decrease peripheral sensation (sensory neuropathy), impair motor coordination (motor neuropathy), and increase postural hypotension (autonomic neuropathy). Together, this can impair overall balance and increase the risk for falls and fractures. In addition, the peripheral nervous system has the potential to regulate bone metabolism directly through the action of local neurotransmitters on bone cells and indirectly through neuroregulation of the skeletal vascular supply.
Summary
This review critically evaluates existing evidence for diabetic peripheral neuropathy as a risk factor or direct actor on bone disease. In addition, we address therapeutic and experimental considerations to guide patient care and future research evaluating the emerging relationship between diabetic neuropathy and bone health.
Springer
