Local intramuscular transplantation of autologous bone marrow mononuclear cells for critical lower limb ischaemia
B Moazzami, Z Mohammadpour… - Cochrane Database …, 2022 - cochranelibrary.com
Cochrane Database of Systematic Reviews, 2022•cochranelibrary.com
Background Peripheral arterial disease is a major health problem, and in about 1% to 2% of
patients, the disease progresses to critical limb ischaemia (CLI), also known as critical limb‐
threatening ischaemia. In a substantial number of individuals with CLI, no effective treatment
options other than amputation are available, with around a quarter of these patients
requiring a major amputation during the following year. This is the second update of a
review first published in 2011. Objectives To evaluate the benefits and harms of local …
patients, the disease progresses to critical limb ischaemia (CLI), also known as critical limb‐
threatening ischaemia. In a substantial number of individuals with CLI, no effective treatment
options other than amputation are available, with around a quarter of these patients
requiring a major amputation during the following year. This is the second update of a
review first published in 2011. Objectives To evaluate the benefits and harms of local …
Background
Peripheral arterial disease is a major health problem, and in about 1% to 2% of patients, the disease progresses to critical limb ischaemia (CLI), also known as critical limb‐threatening ischaemia. In a substantial number of individuals with CLI, no effective treatment options other than amputation are available, with around a quarter of these patients requiring a major amputation during the following year. This is the second update of a review first published in 2011.
Objectives
To evaluate the benefits and harms of local intramuscular transplantation of autologous adult bone marrow mononuclear cells (BMMNCs) as a treatment for CLI.
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