Mitochondria host the machinery for the tricarboxylic acid (TCA) cycle and electron transport
chain (ETC), which generate adenosine triphosphate (ATP) to maintain energy homeostasis.
Glucose, fatty acids, and amino acids are the major energy substrates fueling mitochondrial
respiration in most somatic cells. Evidence shows that different cell types may have a distinct
preference for certain substrates. However, substrate utilization by various cells in the
skeleton has not been studied in detail. Moreover, as cellular metabolism is attuned to …