[HTML][HTML] The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization
M Cubillos-Rojas, F Amair-Pinedo… - Journal of Biological …, 2014 - ASBMB
The tumor suppressor p53 is a transcription factor that coordinates the cellular response to
several kinds of stress. p53 inactivation is an important step in tumor progression.
Oligomerization of p53 is critical for its posttranslational modification and its ability to
regulate the transcription of target genes necessary to inhibit tumor growth. Here we report
that the HECT E3 ubiquitin ligase HERC2 interacts with p53. This interaction involves the
CPH domain of HERC2 (a conserved domain within Cul7, PARC, and HERC2 proteins) and …
several kinds of stress. p53 inactivation is an important step in tumor progression.
Oligomerization of p53 is critical for its posttranslational modification and its ability to
regulate the transcription of target genes necessary to inhibit tumor growth. Here we report
that the HECT E3 ubiquitin ligase HERC2 interacts with p53. This interaction involves the
CPH domain of HERC2 (a conserved domain within Cul7, PARC, and HERC2 proteins) and …
