[HTML][HTML] Donor Batf3 inhibits murine lung allograft rejection and airway fibrosis
T Watanabe, C Lam, J Oliver, H Oishi, G Teskey… - Mucosal …, 2023 - Elsevier
Chronic lung allograft dysfunction (CLAD) limits survival after lung transplantation. Noxious
stimuli entering the airways foster CLAD development. Classical dendritic cells (cDCs) link
innate and adaptive immunity and exhibit regional and functional specialization in the lung.
The transcription factor basic leucine zipper ATF-like 3 (BATF3) is absolutely required for the
development of type 1 cDCs (cDC1s), which reside in the airway epithelium and have
variable responses depending on the context. We studied the role of BATF3 in a mouse …
stimuli entering the airways foster CLAD development. Classical dendritic cells (cDCs) link
innate and adaptive immunity and exhibit regional and functional specialization in the lung.
The transcription factor basic leucine zipper ATF-like 3 (BATF3) is absolutely required for the
development of type 1 cDCs (cDC1s), which reside in the airway epithelium and have
variable responses depending on the context. We studied the role of BATF3 in a mouse …
