Although postoperative bacterial infections can trigger rejection of pulmonary allografts, the
impact of bacterial colonization of donor grafts on alloimmune responses to transplanted
lungs remains unknown. Here, we tested the hypothesis that bacterial products present
within donor grafts at the time of implantation promote lung allograft rejection. Administration
of the toll-like receptor 2 (TLR2) agonist Pam 3 Cys 4 to Balb/c wild-type grafts triggered
acute cellular rejection after transplantation into B6 wild-type recipients that received …