Single-cell RNA sequencing of visceral adipose tissue leukocytes reveals that caloric restriction following obesity promotes the accumulation of a distinct macrophage …
A Weinstock, EJ Brown, ML Garabedian… - …, 2019 - journals.lww.com
Obesity can lead to type 2 diabetes and is an epidemic. A major contributor to its adverse
effects is inflammation of the visceral adipose tissue (VAT). Life-long caloric restriction (CR),
in contrast, results in extended lifespan, enhanced glucose tolerance/insulin sensitivity, and
other favorable phenotypes. The effects of CR following obesity are incompletely
established, but studies show multiple benefits. Many leukocyte types, macrophages
predominantly, reside in VAT in homeostatic and pathological states. CR following obesity …
effects is inflammation of the visceral adipose tissue (VAT). Life-long caloric restriction (CR),
in contrast, results in extended lifespan, enhanced glucose tolerance/insulin sensitivity, and
other favorable phenotypes. The effects of CR following obesity are incompletely
established, but studies show multiple benefits. Many leukocyte types, macrophages
predominantly, reside in VAT in homeostatic and pathological states. CR following obesity …