[HTML][HTML] NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease
R Rau, D Magoon, S Greenblatt, L Li, C Annesley… - Experimental …, 2014 - Elsevier
Cytoplasmic nucleophosmin (NPMc+) mutations and FMS-like tyrosine kinase 3 (FLT3)
internal tandem duplication (ITD) mutations are two of the most common known molecular
alterations in acute myeloid leukemia (AML); they frequently occur together, suggesting
cooperative leukemogenesis. To explore the specific relationship between NPMc+ and
FLT3/ITD in vivo, we crossed Flt3/ITD knock-in mice with transgenic NPMc+ mice. Mice with
both mutations develop a transplantable leukemia of either myeloid or lymphoid lineage …
internal tandem duplication (ITD) mutations are two of the most common known molecular
alterations in acute myeloid leukemia (AML); they frequently occur together, suggesting
cooperative leukemogenesis. To explore the specific relationship between NPMc+ and
FLT3/ITD in vivo, we crossed Flt3/ITD knock-in mice with transgenic NPMc+ mice. Mice with
both mutations develop a transplantable leukemia of either myeloid or lymphoid lineage …
