Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype
K Mrózek - Seminars in oncology, 2008 - Elsevier
Patients with acute myeloid leukemia (AML) harboring three or more acquired chromosome
aberrations in the absence of the prognostically favorable t (8; 21)(q22; q22), inv
(16)(p13q22)/t (6; 16)(p13; q22), and t (15; 17)(q22; q21) aberrations form a separate
category—AML with a complex karyotype. They constitute 10% to 12% of all AML patents,
with the incidence of complex karyotypes increasing with the more advanced age. Recent
studies using molecular-cytogenetic techniques (spectral karyotyping [SKY], multiplex …
aberrations in the absence of the prognostically favorable t (8; 21)(q22; q22), inv
(16)(p13q22)/t (6; 16)(p13; q22), and t (15; 17)(q22; q21) aberrations form a separate
category—AML with a complex karyotype. They constitute 10% to 12% of all AML patents,
with the incidence of complex karyotypes increasing with the more advanced age. Recent
studies using molecular-cytogenetic techniques (spectral karyotyping [SKY], multiplex …
