Phenotypic and functional characterization of mesenchymal stromal cells isolated from pediatric patients with severe idiopathic nephrotic syndrome
N Starc, M Li, M Algeri, A Conforti, L Tomao, A Pitisci… - Cytotherapy, 2018 - Elsevier
Background Idiopathic nephrotic syndrome (INS) is one of the most common renal diseases
in the pediatric population; considering the role of the immune system in its pathogenesis,
corticosteroids are used as first-line immunosuppressive treatment. Due to its chronic nature
and tendency to relapse, a significant proportion of children experience co-morbidity due to
prolonged exposure to corticosteroids and concomitant immunosuppression with second-
line, steroid-sparing agents. Mesenchymal stromal cells (MSCs) are multipotent cells that …
in the pediatric population; considering the role of the immune system in its pathogenesis,
corticosteroids are used as first-line immunosuppressive treatment. Due to its chronic nature
and tendency to relapse, a significant proportion of children experience co-morbidity due to
prolonged exposure to corticosteroids and concomitant immunosuppression with second-
line, steroid-sparing agents. Mesenchymal stromal cells (MSCs) are multipotent cells that …
