Nonhealing wounds represent a significant cause of morbidity and mortality for a large
portion of the population. One of the underlying mechanisms responsible for the failure of
chronic wounds to heal is an out-of-control inflammatory response that is self-sustaining.
Underappreciation of the inherent complexity of the healing wound has led to the failure of
monotherapies, with no significant reduction in wound healing times. A model of the
inflammatory profile of a nonhealing wound is one in which the equilibrium between …