Defective expression and function of the ILT2/CD85j regulatory receptor in dendritic cells from patients with systemic lupus erythematosus
A Monsiváis-Urenda, D Gómez-Martin… - Human immunology, 2013 - Elsevier
Dendritic cells (DCs) play an important role in inducing immune tolerance. Inhibitory
receptors, such as ILT2/CD85j, are involved in the tolerogenic effect of DCs and previous
studies have indicated the important role of these receptors on the pathogenesis of
autoimmune diseases. The aim of this study was to evaluate the expression and function of
ILT2 in DCs from SLE patients. Peripheral blood from fifty patients with SLE and 38 healthy
volunteers was obtained. ILT2 expression was assessed by flow cytometry. DCs were …
receptors, such as ILT2/CD85j, are involved in the tolerogenic effect of DCs and previous
studies have indicated the important role of these receptors on the pathogenesis of
autoimmune diseases. The aim of this study was to evaluate the expression and function of
ILT2 in DCs from SLE patients. Peripheral blood from fifty patients with SLE and 38 healthy
volunteers was obtained. ILT2 expression was assessed by flow cytometry. DCs were …
